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KMID : 0043319980210020168
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Archives of Pharmacal Research
1998 Volume.21 No. 2 p.168 ~ p.173
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Epoxyalkanoyls as Novel ACE Inhibitors
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P. Choo Hea-Young
Yoon Hea-Ran
Park Hwha-Soon
Kim Dong-Hyun
Park Jong-Sei
Kim Dong-H.
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Abstract
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The epoxyalkanoyl derivatives were designed and synthesized as ACE inhibitors. Coupling of unsaturated carboxylic acids with amino acids and following epoxidation with dimethyldioxirane gave the epoxyalkanoyls with high yield. The inhibitory activity of synthesized compounds on angiotensin converting enzyme was values of 0.06~5.5
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KEYWORD
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Epoxides, Angiotensin converting enzyme inhibitor, Irreversible inhibition
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